Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France.
Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France; Nash Family Department of Neuroscience, Center for Affective Neuroscience, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Trends Pharmacol Sci. 2019 Sep;40(9):696-710. doi: 10.1016/j.tips.2019.07.007. Epub 2019 Aug 7.
Neuronal communication involves a multitude of neurotransmitters and an outstanding diversity of receptors and ion channels. Linking the activity of cell surface receptors and ion channels in defined neural circuits to brain states and behaviors has been a key challenge in neuroscience, since cell targeting is not possible with traditional neuropharmacology. We review here recent technologies that enable the effect of drugs to be restricted to specific cell types, thereby allowing acute manipulation of the brain's own proteins with circuit specificity. We highlight the importance of developing cell-specific neuropharmacology strategies for decoding the nervous system with molecular and circuit precision, and for developing future therapeutics with reduced side effects.
神经元通讯涉及多种神经递质以及多种多样的受体和离子通道。将特定神经回路中细胞表面受体和离子通道的活性与脑状态和行为联系起来，一直是神经科学的一个关键挑战，因为传统神经药理学无法靶向特定的细胞。我们在这里回顾了最近的一些技术，这些技术使药物的作用能够局限于特定的细胞类型，从而可以对大脑自身的蛋白质进行具有特定回路的急性操作。我们强调了开发细胞特异性神经药理学策略的重要性，该策略可以实现分子和回路特异性解码神经系统，并开发副作用更小的未来治疗方法。
