Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China.
Biotechnology Research Group, Deportment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Eur J Med Chem. 2019 Nov 1;181:111566. doi: 10.1016/j.ejmech.2019.111566. Epub 2019 Jul 29.
The worldwide increase of AIDS, an epidemic infection in constant development has an essential and still requires potent antiretroviral chemotherapeutic agents for reducing the integer of deaths caused by HIV. Thus, there is an urgent need for new anti-HIV drug candidates with increased strength, new targets, superior pharmacokinetic properties, and compact side effects. From this viewpoint, we first review present strategies of anti-HIV drug innovation and the synthesis of heterocyclic or natural compound as anti-HIV agents for facilitating the development of more influential and successful anti-HIV agents.
全世界艾滋病的不断发展，是一种流行感染，需要强有力的抗逆转录病毒化学疗法来减少由 HIV 引起的死亡人数。因此，迫切需要具有更强效力、新靶点、更好药代动力学特性和更小副作用的新型抗 HIV 药物候选物。从这个角度来看，我们首先回顾了目前的抗 HIV 药物创新策略以及杂环或天然化合物作为抗 HIV 药物的合成，以促进更有影响力和成功的抗 HIV 药物的发展。
