Moustafa Hany Samir, Qotb Mohamed, Hussein Mohammed Ahmed, Eid Ahmed, Ayad Essam Ezzat, Fawzy Tamer
Faculty of Medicine Hospital, University of Fayoum, Faiyum, Egypt.
Sahel Teaching Hospital Cairo, Cairo, Egypt.
ORL J Otorhinolaryngol Relat Spec. 2019;81(5-6):274-280. doi: 10.1159/000500990. Epub 2019 Aug 9.
Interleukin-25 (IL-25) is an important contributing factor in the pathogenesis of allergic rhinitis. It leads to increasing peripheral and infiltrating eosinophilia as well as serum IgE, IgG, and Th2 cytokines (IL-4, IL-5, IL-13), which are responsible for the allergic symptoms. Intranasal steroids (INS) are effective in treating allergic rhinitis, but their effect on IL-25 release has not been studied. We aimed to study the link between IL-25 and the pathophysiology of allergic rhinitis as well as the effect of INS on its release.
This was a cohort, prospective, nonrandomized study that included 60 patients, 35 allergic rhinitis patients and 25 controls. We studied the effect of INS on IL-25 release.
Of allergic rhinitis patients 68.6% had strong cytoplasmic stain of IL-25 in the epithelial layer, while 25.7% had intermediate stain. INS caused significantly reduced IL-25 stain as only 14.3% of patients had intermediate stain and 85.7% had weak stain. Moreover, a correlation was found between nasal smear eosinophilia and the degree of IL-25 staining in the epithelial layer.
Intranasal corticosteroids appear to be effective in the downregulation of IL-25, which may explain some of the utility of intranasal corticosteroid treatment in improving allergic rhinitis symptoms.
白细胞介素-25（IL-25）是变应性鼻炎发病机制中的一个重要促成因素。它导致外周及浸润性嗜酸性粒细胞增多以及血清IgE、IgG和Th2细胞因子（IL-4、IL-5、IL-13）增加，而这些细胞因子会引发过敏症状。鼻用类固醇（INS）对治疗变应性鼻炎有效，但尚未对其对IL-25释放的影响进行研究。我们旨在研究IL-25与变应性鼻炎病理生理学之间的联系以及INS对其释放的影响。
这是一项队列、前瞻性、非随机研究，纳入了60例患者，其中35例为变应性鼻炎患者，25例为对照组。我们研究了INS对IL-25释放的影响。
在变应性鼻炎患者中，68.6%的患者在上皮层有强烈的IL-25细胞质染色，而25.7%的患者有中等染色。INS导致IL-25染色显著降低，因为只有14.3%的患者有中等染色，85.7%的患者有弱染色。此外，鼻涂片嗜酸性粒细胞增多与上皮层IL-25染色程度之间存在相关性。
鼻用皮质类固醇似乎能有效下调IL-25，这可能解释了鼻用皮质类固醇治疗在改善变应性鼻炎症状方面的一些作用。
