Komlos L, Shimberg R, Halbrecht I, Zohar Y, Strauss M, Laurian L, Laurian N
B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Petah-Tiqva, Israel.
Otolaryngol Head Neck Surg. 1988 Jul;99(1):10-5. doi: 10.1177/019459988809900102.
Many thyroid carcinomas seem to be dependent upon the thyroid growth-promoting properties of the thyroid stimulating hormone (TSH). The purpose of the present investigation was to compare the in vitro effect of TSH on tissue cultures derived from malignant and benign thyroid tumors. The results indicate that TSH can affect the morphology and protein synthesis of primary tissue cultures derived from benign and malignant thyroid tumors differently. The addition of TSH to cultures derived from benign tumors resulted in a reorganization of follicle-like structures of the monolayer and in a reduction of protein synthesis. In contrast to this, monolayers derived from carcinomas of the thyroid were not able to reorganize and their protein synthesis was not inhibited in the presence of TSH. For a better understanding of TSH suppressive therapy, we suggest testing the influence of TSH on a large number of tissue cultures derived from benign and malignant tumors of the thyroid.
许多甲状腺癌似乎依赖于促甲状腺激素（TSH）促进甲状腺生长的特性。本研究的目的是比较TSH对源自恶性和良性甲状腺肿瘤的组织培养物的体外作用。结果表明，TSH对源自良性和恶性甲状腺肿瘤的原代组织培养物的形态和蛋白质合成的影响不同。向源自良性肿瘤的培养物中添加TSH导致单层细胞中卵泡样结构的重组以及蛋白质合成的减少。与此相反，源自甲状腺癌的单层细胞无法重组，并且在存在TSH的情况下其蛋白质合成未受到抑制。为了更好地理解TSH抑制疗法，我们建议测试TSH对大量源自甲状腺良性和恶性肿瘤的组织培养物的影响。
