Department of Microbiology, AMITY University Rajasthan , Jaipur , India.
Translational Health Science & Technology Institute , Faridabad , India.
Int Rev Immunol. 2019;38(5):204-211. doi: 10.1080/08830185.2019.1648453. Epub 2019 Aug 12.
The newly discovered Th9 cells are the distinct subset of CD4 T helper (Th) cells, which are involved in various pathophysiological conditions of an immune response. In addition to its role in allergic inflammation and elimination of extracellular pathogens, Th9 cells were found to play a key role in inducing anti-tumor immune response. Precisely, the anti-tumor functions of Th9 cells were found to be superior as compared to Th1 and other Th subsets. Th9 cells eliminate tumors via activating innate and adaptive immune cells, and in particular, generating a profound effector cytotoxic T lymphocyte (CTL) response against neo antigens. In addition, it was proposed that Th9 cells were found to induce effector functions of innate cells like dendritic cells, mast cells and NK cells, which further promote a robust anti-tumor immune response. In this review, we highlight the recent advances in differentiation and functions of Th9 cells in anti-tumor immunity.
新发现的 Th9 细胞是 CD4+辅助性 T 细胞（Th）的一个独特亚群，参与免疫反应的各种病理生理条件。除了在过敏炎症和清除细胞外病原体中的作用外，还发现 Th9 细胞在诱导抗肿瘤免疫反应中发挥关键作用。确切地说，与 Th1 和其他 Th 亚群相比，Th9 细胞的抗肿瘤功能更为优越。Th9 细胞通过激活先天和适应性免疫细胞来消除肿瘤，特别是针对新抗原产生强烈的效应细胞毒性 T 淋巴细胞（CTL）反应。此外，有人提出，Th9 细胞被发现能够诱导树突状细胞、肥大细胞和 NK 细胞等先天细胞的效应功能，从而进一步促进强大的抗肿瘤免疫反应。在这篇综述中，我们强调了 Th9 细胞在抗肿瘤免疫中的分化和功能的最新进展。
