Goldstein M, Stonestreet B S, Brann B S, Oh W
Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence.
Pediatr Res. 1988 Oct;24(4):486-9. doi: 10.1203/00006450-198810000-00014.
Our study tests the hypothesis that hyperviscosity independent of arterial O2 content reduces cerebral cortical blood flow, O2 delivery, and O2 uptake. After baseline determinations, ten 2- to 4-day-old awake spontaneously breathing piglets were given an intravenous infusion (5 ml.kg-1, body weight) of concentrated cryoprecipitate, whereas eight controls received normal saline. Cerebral cortical blood flow, arterial and superior sagittal sinus O2 content, whole blood viscosity, hematocrit, blood gases, and plasma fibrinogen concentrations were measured at baseline and 3 h after infusion. No significant changes were observed in the control group. Three hours after the infusion of concentrated cryoprecipitate the experimental group showed an increase in whole blood viscosity, whereas hematocrit and arterial O2 content were unchanged. There was a decrease in cerebral cortical blood flow and cerebral cortical O2 delivery, whereas cerebral cortical O2 uptake was unchanged. We conclude that hyperviscosity independent of arterial O2 content reduces cerebral cortical blood flow and that although O2 delivery was reduced in the newborn piglet cerebral cortical O2 uptake was maintained.
我们的研究检验了这样一个假设，即与动脉血氧含量无关的高黏滞血症会降低大脑皮质血流量、氧输送和氧摄取。在进行基线测定后，给10只2至4日龄自发呼吸的清醒仔猪静脉输注（5毫升·千克⁻¹体重）浓缩冷沉淀，而8只对照仔猪接受生理盐水。在基线和输注后3小时测量大脑皮质血流量、动脉和上矢状窦血氧含量、全血黏度、血细胞比容、血气以及血浆纤维蛋白原浓度。对照组未观察到显著变化。输注浓缩冷沉淀3小时后，实验组全血黏度增加，而血细胞比容和动脉血氧含量未变。大脑皮质血流量和大脑皮质氧输送减少，而大脑皮质氧摄取未变。我们得出结论，与动脉血氧含量无关的高黏滞血症会降低大脑皮质血流量，并且尽管新生仔猪大脑皮质的氧输送减少，但氧摄取得以维持。
