Rhodes R A, Skerven G, Chey W Y, Chang T M
Gastroenterology Section, Marshfield Clinic, WI 54449.
Pancreas. 1988;3(4):391-8. doi: 10.1097/00006676-198808000-00004.
In order to clarify a possible role of fat content in the release of secretin and cholecystokinin by liquid nutritional supplements in humans, duodenal pH and plasma concentrations of secretin and cholecystokinin were studied during the intraduodenal infusion of Ensure, Vivonex, 10% Intralipid, and sodium oleate. Significant release of secretin was observed with Intralipid and sodium oleate, while significant release of cholecystokinin was observed with all four testing solutions. Duodenal pH was rarely below 4.5 during the infusion of Ensure, Intralipid, and sodium oleate. Duodenal pH was high, greater than 6.0, when plasma secretin and cholecystokinin levels were elevated during the administration of Ensure, Intralipid, and sodium oleate. We conclude that both secretin and cholecystokinin are released in response to fat solutions in the duodenum and that low duodenal pH was not responsible for either secretin or cholecystokinin release during intraduodenal infusions of Ensure, Intralipid, or sodium oleate.
为了阐明脂肪含量在液体营养补充剂对人体促胰液素和胆囊收缩素释放过程中可能发挥的作用，在十二指肠内输注安素、维沃素、10% 英脱利匹特和油酸钠期间，对十二指肠pH值以及促胰液素和胆囊收缩素的血浆浓度进行了研究。观察到英脱利匹特和油酸钠可使促胰液素显著释放，而所有四种测试溶液均可使胆囊收缩素显著释放。在输注安素、英脱利匹特和油酸钠期间，十二指肠pH值很少低于4.5。在输注安素、英脱利匹特和油酸钠期间，当血浆促胰液素和胆囊收缩素水平升高时，十二指肠pH值较高，大于6.0。我们得出结论，促胰液素和胆囊收缩素均会因十二指肠内的脂肪溶液而释放，并且在十二指肠内输注安素、英脱利匹特或油酸钠期间，十二指肠pH值较低并非促胰液素或胆囊收缩素释放的原因。
