Schade C P, Komorwska D
Department of Human Services, Multnomah County, OR.
Public Health Rep. 1988 Sep-Oct;103(5):452-9.
A communitywide outbreak of hepatitis A occurred in Portland, OR, from 1983 through 1986. At the peak of the outbreak, the age- and sex-specific annual incidence rate approached 400 cases per 100,000 population among men ages 25 to 34, the highest risk group. The community incidence rate was nearly 10 times the relevant national incidence rate. A review of the records concerning cases of hepatitis A reported in the last 6 months of 1985 revealed that about half the number of young adults whose cases were investigated during that time reported a history of intravenous (IV) drug use--a proportion about 50 times greater than expected among persons in that age range. A simultaneous epidemic of overdose deaths from heroin and a concomitant increase in hepatitis B incidence rates led to the suspicion that this was a drug-abuse-associated epidemic of hepatitis among new IV drug users. Control of this outbreak was difficult because the population most at risk was distrustful of public health officials. Increased surveillance in food service establishments and schools might have prevented outbreaks from a common source in the general population; however, an increase of sporadic cases in the nondrug-using population clearly occurred.
1983年至1986年期间,俄勒冈州波特兰市爆发了甲型肝炎社区疫情。在疫情高峰期,25至34岁男性这一最高风险群体中,按年龄和性别划分的年发病率接近每10万人400例。社区发病率几乎是全国相关发病率的10倍。对1985年最后6个月报告的甲型肝炎病例记录进行审查发现,在此期间接受调查的年轻成年人中,约有一半报告有静脉注射吸毒史,这一比例比该年龄范围内人群的预期比例高出约50倍。同时发生的海洛因过量致死疫情以及乙型肝炎发病率的相应上升,引发了人们对这是新的静脉注射吸毒者中与药物滥用相关的甲型肝炎疫情的怀疑。此次疫情的控制难度很大,因为风险最高的人群不信任公共卫生官员。加强对食品服务场所和学校的监测或许可以预防普通人群中共同来源引发的疫情;然而,非吸毒人群中散发病例明显增加。