脱氧鞘脂类和醚连接的二酰基甘油在老年小鼠的组织中积累。
Deoxysphingolipids and ether-linked diacylglycerols accumulate in the tissues of aged mice.
作者信息
Ando Ayumi, Oka Masahiro, Satomi Yoshinori
机构信息
1Integrated Technology Research Laboratories, Takeda Pharmaceutical Company, Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555 Japan.
2Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555 Japan.
出版信息
Cell Biosci. 2019 Aug 5;9:61. doi: 10.1186/s13578-019-0324-9. eCollection 2019.
BACKGROUND
Senescence is a well-known risk factor for several diseases, such as neurodegenerative disorders. Therefore, studies exploring the mechanisms underlying aging are expected to guide the discovery of novel drug targets and biomarkers for these diseases. However, a comprehensive overview of the metabolic and lipidomic changes in healthy aging mammals is lacking. To understand the changes of metabolism with aging, especially lipid metabolism, we analyzed the metabolomes and lipidomes of the cerebral cortex, liver, femoral muscle, and epididymal fat in young and aged mice.
RESULTS
Two-dimensional cluster analysis revealed clear separation between the metabolite profiles of the aged and young groups. Deoxydihydroceramide (doxDHCer), deoxyceramide (doxCer), and ether-linked diacylglycerol (DAG) levels were elevated during aging.
CONCLUSION
This is the first report of age-related variations in deoxysphingolipid and ether-linked DAG levels in mice. DoxCer, doxDHCer, and ether-linked DAGs may be associated with senescence in mammalian tissues.
背景
衰老众所周知是多种疾病的风险因素，如神经退行性疾病。因此，探索衰老潜在机制的研究有望指导这些疾病新药物靶点和生物标志物的发现。然而，目前缺乏对健康衰老哺乳动物代谢和脂质组变化的全面概述。为了解衰老过程中的代谢变化，特别是脂质代谢，我们分析了年轻和老年小鼠大脑皮层、肝脏、股四头肌和附睾脂肪的代谢组和脂质组。
结果
二维聚类分析显示老年组和年轻组的代谢物谱有明显分离。衰老过程中脱氧二氢神经酰胺（doxDHCer）、脱氧神经酰胺（doxCer）和醚连接二酰甘油（DAG）水平升高。
结论
这是关于小鼠中脱氧鞘脂和醚连接DAG水平与年龄相关变化的首次报道。DoxCer、doxDHCer和醚连接DAG可能与哺乳动物组织衰老有关。
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