侵袭性前列腺癌变异型的临床病理诊断方法。
Clinicopathologic Diagnostic Approach to Aggressive Variant Prostate Cancer.
机构信息
From the Department of Pathology (Dr Manucha) and the Division of Hematology/Oncology, Department of Medicine (Dr Henegan), University of Mississippi Medical Center, Jackson.
出版信息
Arch Pathol Lab Med. 2020 Jan;144(1):18-23. doi: 10.5858/arpa.2019-0124-RA. Epub 2019 Aug 12.
CONTEXT.—: Aggressive variant prostate cancer (AVPCa) develops in a subset of patients with metastatic castration-resistant prostate cancer. The clinical and histologic overlap of AVPCa with other neuroendocrine carcinomas of the prostate has resulted in a lack of consensus on its terminology and treatment.
OBJECTIVE.—: To review AVPCa to familiarize pathologists with this entity so they can actively participate in the detection, ongoing research, and evolving management of AVPCa.
DATA SOURCES.—: The English language literature was reviewed.
CONCLUSIONS.—: The current review summarizes the pathologic features of AVPCa, describes how it has been defined clinically, and discusses how biomarkers may inform treatment strategies in the future.
背景
侵袭性变异前列腺癌（AVPCa）发生在转移性去势抵抗性前列腺癌患者的亚组中。AVPCa 与前列腺其他神经内分泌癌在临床和组织学上存在重叠，导致其术语和治疗方法缺乏共识。
目的
回顾侵袭性变异前列腺癌，使病理学家熟悉这一实体，以便能够积极参与 AVPCa 的检测、持续研究和不断发展的管理。
资料来源
对英文文献进行了回顾。
结论
本次综述总结了 AVPCa 的病理特征，描述了其在临床上的定义，并讨论了生物标志物如何在未来为治疗策略提供信息。
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