Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec International Hospital, Ha Noi, Vietnam.
Skin Research Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
J Eur Acad Dermatol Venereol. 2019 Dec;33(12):2264-2272. doi: 10.1111/jdv.15859. Epub 2019 Sep 9.
Keratinocytes, which constitute 90% of the cells in the epidermis of the skin, have been demonstrated to communicate with other skin cells such as fibroblasts, melanocytes and immune cells through extracellular vesicles (EVs). This communication is facilitated by the enriched EV biomolecular cargo which regulates multiple biological processes within skin tissue, including cell proliferation, cell migration, anti-apoptosis, pigmentation transfer and extracellular matrix remodelling. This review will provide an overview of the current literature and advances in the field of keratinocyte-derived EV research with particular regard to the interactions and communication between keratinocytes and other skin cells, mediated by EVs and EV components. Importantly, this information may shed some light on the potential for keratinocyte-derived EVs in future biomedical studies.
角质形成细胞构成了皮肤表皮 90%的细胞，已被证明可通过细胞外囊泡（EV）与成纤维细胞、黑素细胞和免疫细胞等其他皮肤细胞进行通讯。这种通讯是通过富含 EV 生物分子货物来实现的，它调节皮肤组织内的多种生物学过程，包括细胞增殖、细胞迁移、抗细胞凋亡、色素转移和细胞外基质重塑。本文综述了角质形成细胞衍生的 EV 研究领域的当前文献和进展，特别关注 EV 及其成分介导的角质形成细胞与其他皮肤细胞之间的相互作用和通讯。重要的是，这些信息可能为未来角质形成细胞衍生的 EV 在生物医学研究中的应用提供一些启示。
