Chentanez T, Patradilok P, Glinsukon T, Piyachaturawat P
Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Toxicol Lett. 1988 Sep;42(3):237-48. doi: 10.1016/0378-4274(88)90108-7.
Effects of cortisol pretreatment on acute hepatotoxicity induced by aflatoxin B1 (AFB1) were investigated in female rats. Pretreatment of cortisol (1.0-10.0 mg/kg body weight) for 7 consecutive days markedly increased mortality rate, activity of plasma glutamic pyruvic transaminase (PGPT), plasma glutamic oxaloacetic transaminase (PGOT) and liver triglycerides induced by AFB1 (3.0 mg/kg body weight). The potentiating action of cortisol on hepatic necrosis of AFB1 showed a dose-dependent pattern. The possible mechanism of its action may be related to an increase in the activity of aniline hydroxylase and formation of AFB1-2,3-epoxide which in turn caused a marked increase in AFB1 binding to hepatic DNA and proteins, and lipid peroxide formation. Therefore, the potentiating action of cortisol on AFB1 hepatotoxicity may possibly increase the damage to DNA and membranes of various organelles.
在雌性大鼠中研究了皮质醇预处理对黄曲霉毒素B1（AFB1）诱导的急性肝毒性的影响。连续7天给予皮质醇（1.0 - 10.0mg/kg体重）预处理显著增加了由AFB1（3.0mg/kg体重）诱导的死亡率、血浆谷丙转氨酶（PGPT）活性、血浆谷草转氨酶（PGOT）活性和肝脏甘油三酯含量。皮质醇对AFB1肝坏死的增强作用呈剂量依赖性。其作用的可能机制可能与苯胺羟化酶活性增加以及AFB1 - 2,3 - 环氧化物的形成有关，这反过来又导致AFB1与肝DNA和蛋白质的结合显著增加以及脂质过氧化物的形成。因此，皮质醇对AFB1肝毒性的增强作用可能会增加对各种细胞器DNA和膜的损伤。
