疱疹病毒、自身免疫和癫痫：肽共享以及与人类突触蛋白的潜在交叉反应性。

Herpesviruses, autoimmunity and epilepsy: Peptide sharing and potential cross-reactivity with human synaptic proteins.

机构信息

University of Greifswald, Department of Neurology, Ferdinand-Sauerbruch-Straße, Greifswald 17495, Germany; Goldsmiths, University of London, Department of Computing, Lewisham Way, New Cross, London SE14 6NW, United Kingdom.

出版信息

Autoimmun Rev. 2019 Oct;18(10):102367. doi: 10.1016/j.autrev.2019.102367. Epub 2019 Aug 9.

DOI:10.1016/j.autrev.2019.102367

PMID:31404705

Abstract

Aggregation of immuno-proteomic data reveals that i) herpesviruses and synaptic proteins -in particular Synapsin-1 and Bassoon - share a large number of hexapeptides that also recur in hundreds of epitopes experimentally validated as immunopositive in the human host, and ii) the shared peptides are also spread among human epilepsy-related proteins. The data indicate that cross-reactive processes may be associated with pathogenetic mechanisms in epilepsy, thus suggesting a role of autoimmunity in etiopathology of epilepsies after herpesvirus-infections.

摘要

免疫蛋白质组学数据的聚集表明

i）疱疹病毒和突触蛋白 - 特别是突触素 1 和 Bassoon - 共享大量六肽，这些六肽也在数百个实验验证为人类宿主免疫阳性的表位中反复出现；ii）共享的肽也分布在人类与癫痫相关的蛋白质中。这些数据表明，交叉反应过程可能与癫痫的发病机制有关，因此提示疱疹病毒感染后癫痫的发病机制中可能存在自身免疫作用。