Sports Medicine Department, Huashan Hospital Fudan University, Shanghai, China.
Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Int J Sports Med. 2019 Oct;40(11):683-695. doi: 10.1055/a-0902-8539. Epub 2019 Aug 12.
The purpose of this study was to conduct an up-to-date systematic review and meta-analysis of radiographic knee osteoarthritis (OA) over minimal ten years after ACL reconstruction. The database of Pubmed and the Ovid was adopted. The radiographic knee OA over minimal ten years after ACL reconstruction was systematically reviewed. Both the ipsilateral and contralateral knees were evaluated referring to the tibiofemoral joint (TFJ), the patellofemoral joint (PFJ), and the overall knee OA prevalence. Nineteen studies were included for review, with nine screened for the meta-analysis. The overall knee OA rate ranged from 8.3-79.2%, meanly 51.6% on the ipsilateral side; ranged from 3.6-35.7%, meanly 15.5% on the contralateral side. Compared to the contralateral side, the RR of developing radiographic OA was 3.73 (P<0.01) for the overall knee, 2.88 (P<0.01) for TFJ, and 2.42 (P<0.01) for PFJ. Ipsilaterally, the RR of developing TFJ radiographic OA was 1.15 (P<0.01) compared to that of the PFJ. Over a minimum of 10 years after surgery, more than half the cases developed overall radiographic OA on the ipsilateral knee, which was nearly four times higher than the contralateral side. On the ipsilateral knee, the TFJ was most affected.
本研究旨在对 ACL 重建后至少 10 年的膝关节放射学骨关节炎（OA）进行最新的系统回顾和荟萃分析。采用 Pubmed 和 Ovid 数据库。系统地回顾了 ACL 重建后至少 10 年的放射学膝关节 OA。参照胫股关节（TFJ）、髌股关节（PFJ）和总体膝关节 OA 患病率，评估同侧和对侧膝关节。共纳入 19 项研究进行综述，其中 9 项进行荟萃分析。总体膝关节 OA 发生率范围为 8.3-79.2%，平均为 51.6%在同侧；范围为 3.6-35.7%，平均为 15.5%在对侧。与对侧相比，整体膝关节、TFJ 和 PFJ 发生放射学 OA 的 RR 分别为 3.73（P<0.01）、2.88（P<0.01）和 2.42（P<0.01）。同侧 TFJ 放射学 OA 的 RR 高于 PFJ，为 1.15（P<0.01）。在手术后至少 10 年，超过一半的病例同侧膝关节出现总体放射学 OA，几乎是对侧的四倍。在同侧膝关节中，TFJ 受影响最大。
