Rafati Mehravar, Rahimzadeh Mehrdad Rafati, Moladoust Hassan
Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Department of Nursing, Babol University of Medical Sciences, Babol, Iran.
Ultrasound Med Biol. 2019 Nov;45(11):2950-2957. doi: 10.1016/j.ultrasmedbio.2019.07.412. Epub 2019 Aug 9.
This study aimed to identify instant intima-media thickness changes (ΔIMT) in the common carotid artery (CCA) during cardiac cycle in order to assess atherosclerosis progression. Using a computerized semi-automated method, instant IMT changes were extracted in the two walls of the left CCA (240 consecutive patients) using B-mode ultrasound images. We found that CCA ΔIMT increased from 8 ± 4% of IMT in the controls to 15 ± 6% of IMT in the severe stenosis group. According to the multiple ordinal regression analysis, ΔIMT was associated with the severity of carotid artery stenosis (odds ratio [OR], 4.95; p < 0.001), independent of sex (OR, 1.11; p = 0.04), age (OR, 1.14; p < 0.001), body mass index; OR, 1.13; p = 0.036), hypertension (OR, 2.04; p < 0.001), diabetes (OR, 1.38; p = 0.045) and hyperlipidemia (OR, 1.54; p = 0.002). We concluded that increment of CCA ΔIMT during the cardiac cycle was strongly and independently associated with severity of carotid artery stenosis or atherosclerosis progression.
本研究旨在确定心动周期中颈总动脉（CCA）的即时内膜中层厚度变化（ΔIMT），以评估动脉粥样硬化的进展。使用计算机半自动方法，利用B超图像提取了左颈总动脉两壁（240例连续患者）的即时IMT变化。我们发现，颈总动脉ΔIMT从对照组IMT的8±4%增加到严重狭窄组IMT的15±6%。根据多序回归分析，ΔIMT与颈动脉狭窄的严重程度相关（优势比[OR]，4.95；p<0.001），与性别（OR，1.11；p = 0.04）、年龄（OR，1.14；p<0.001）、体重指数（OR，1.13；p = 0.036）、高血压（OR，2.医.学全在.med126.com204；p<0.001）、糖尿病（OR，1.38；p = 0.045）和高脂血症（OR，1.54；p = 0.002）无关。我们得出结论，心动周期中颈总动脉ΔIMT的增加与颈动脉狭窄的严重程度或动脉粥样硬化的进展密切且独立相关。
