Hayashi N, Sugimura Y, Hori N, Yamamoto I, Tazima K, Tochigi H, Kawamura J
Department of Urology, Mie University School of Medicine.
Hinyokika Kiyo. 1988 May;34(5):847-50.
Clomiphene citrate therapy was performed on 30 patients with idiopathic male infertility, who were intractable to non-hormonal therapy. Clomiphene citrate was administered orally at a dose of 25 mg per day for 25 days with 5 days of rest following Paulson' protocol, and we favorable results were obtained: Both sperm count and sperm motility improved in 11 cases (36.7%). Odera's score count decreased in 14 cases (46.7%), which were judged as effective. The wives of 4 patients treated by this therapy became pregnant. After this therapy, the serum levels of luteinizing hormone, follicle stimulating hormone, testosterone and prolactin were 1.90, 1.81, 1.89 and 1.22 times higher, respectively. These findings indicate that clomiphene citrate therapy is an effective for idiopathic male infertility, but we need to consider that the sudden and marked elevation of serum testosterone level by this therapy might affect male accessory sex organs such as the prostatic gland which shows androgen dependency later in life.
对30例对非激素治疗无效的特发性男性不育患者进行了枸橼酸氯米芬治疗。按照保尔森方案，口服枸橼酸氯米芬，剂量为每日25mg，共25天，随后休息5天，取得了良好效果：11例（36.7%）患者的精子数量和精子活力均有所改善。14例（46.7%）患者的奥德雷评分降低，判定为有效。接受该治疗的4例患者的妻子怀孕。治疗后，黄体生成素、卵泡刺激素、睾酮和催乳素的血清水平分别升高了1.90倍、1.81倍、1.89倍和1.22倍。这些结果表明，枸橼酸氯米芬治疗对特发性男性不育有效，但我们需要考虑到，该治疗导致血清睾酮水平突然显著升高，可能会影响男性附属性腺器官，如前列腺，而前列腺在生命后期表现出雄激素依赖性。
