Barnes Stephanie L, Simon Neil G
Department of Neurology, Concord Repatriation General Hospital, Concord, NSW, Australia.
St Vincent's Clinical School, School of Medicine, The University of Notre Dame Australia, Sydney, NSW, Australia.
Degener Neurol Neuromuscul Dis. 2019 Jul 16;9:89-102. doi: 10.2147/DNND.S215318. eCollection 2019.
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by dysfunction at multiple levels of the neuraxis. It remains a clinical diagnosis without a definitive diagnostic investigation. Electrodiagnostic testing provides supportive information and, along with imaging and biochemical markers, can help exclude mimicking conditions. Neuromuscular ultrasound has a valuable role in the diagnosis and monitoring of ALS and provides complementary information to clinical assessment and electrodiagnostic testing as well as insights into the underlying pathophysiology of this disease. This review highlights the evidence for ultrasound in the evaluation of bulbar, limb and respiratory musculature and peripheral nerves in ALS. Further research in this evolving area is required.
肌萎缩侧索硬化症（ALS）是一种毁灭性的神经退行性疾病，其特征是在神经轴的多个水平上出现功能障碍。它仍然是一种临床诊断，没有确定性的诊断检查方法。电诊断测试提供支持性信息，并且与影像学和生化标志物一起，可以帮助排除疑似病症。神经肌肉超声在ALS的诊断和监测中具有重要作用，为临床评估和电诊断测试提供补充信息，并有助于深入了解该疾病的潜在病理生理学。本综述强调了超声在评估ALS患者的延髓、肢体和呼吸肌肉以及周围神经方面的证据。在这个不断发展的领域还需要进一步的研究。
