Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
J Mol Neurosci. 2020 Jan;70(1):26-31. doi: 10.1007/s12031-019-01395-9. Epub 2019 Aug 13.
The cannabinoid system has been identified as a critical endogenous regulator of immune homeostasis through immunomodulatory actions. This system is one of the main regulatory systems of the central nervous system (CNS). Variations in the cannabinoid CB2 receptor gene (CNR2) could affect intracellular signaling and reduce system function, which has been associated with an unbalanced immune response and increased risk of a variety of autoimmune inflammatory disorders. The present study investigated the relationship between CNR2 rs35761398 (Q63R) functional variation and multiple sclerosis (MS). A total of 100 Iranian MS patients and 100 healthy controls were enrolled in the study and genotyped through TaqMan assay. The co-dominant, dominant, recessive, over-dominant, and additive inheritance models were analyzed using SNPStats software. A significant genetic association was observed between Q63R polymorphism and MS. The dominant model was accepted as the best inheritance model to fit the data (OR 2.70, 95% CI 1.47-4.97, p = 0.001). The data implied the involvement of the CNR2 gene in susceptibility to MS in Iranian patients.
大麻素系统已被确定为通过免疫调节作用对免疫稳态的关键内源性调节剂。该系统是中枢神经系统 (CNS) 的主要调节系统之一。大麻素 CB2 受体基因 (CNR2) 的变异可能会影响细胞内信号转导并降低系统功能，这与不平衡的免疫反应和增加多种自身免疫性炎症性疾病的风险有关。本研究探讨了 CNR2 rs35761398 (Q63R) 功能变异与多发性硬化症 (MS) 之间的关系。本研究共纳入 100 名伊朗 MS 患者和 100 名健康对照者，并通过 TaqMan 分析进行基因分型。使用 SNPStats 软件分析了共显性、显性、隐性、过显性和加性遗传模型。Q63R 多态性与 MS 之间存在显著的遗传关联。显性模型被接受为拟合数据的最佳遗传模型 (OR 2.70, 95% CI 1.47-4.97, p = 0.001)。数据表明 CNR2 基因参与了伊朗患者 MS 的易感性。
