Makarov I Yu, Gorikov I N, Zabolotskikh T V, Menshchikova N V, Menshchikov A O, Nakhamchen L G, Andrievskaya I A, Ishutina N A, Dovzhikova I V
Amur State Medical Academy, Ministry of Health of Russia, Blagoveshchensk, Russia.
Far Eastern Research Center for Physiology and Pathology of Respiration, Blagoveshchensk, Russia.
Arkh Patol. 2019;81(4):39-42. doi: 10.17116/patol20198104139.
To study placental morphometric parameters in women who have experienced mono- and mixed viral respiratory infections during pregnancy.
Three groups of placentas were studied. Group 1 consisted of 25 placentas from women with physiological pregnancy; Group 2 included 25 placentas from those who had experienced parainfluenza type 3; and Group 3 comprised 25 placentas from those who had mixed respiratory viral infection (parainfluenza type 3 concurrent with influenza A (H3N2)) in the second trimester of pregnancy. The weight of the placenta and its morphometric parameters were determined on hematoxylin and eosin stained tissue sections using a square multifaceted stereometric grid placed in the microscopic eyepiece (magnification 15×20).
Group 3 versus Group 2 exhibited a reduction in placental weights along with an increase in the stroma, fibrinoid around the villi and in the stroma, pseudonecroses, calcification, intermediate immature villi, small avascular villi, and hemorrhages in the intervillous space and a decrease the volume of the circulatory bed.
In women in the second trimester of pregnancy, mixed viral respiratory infection has a more pronounced negative impact on the formation of the placenta.
研究孕期发生单纯性和混合性病毒性呼吸道感染的女性的胎盘形态学参数。
研究三组胎盘。第1组由25例生理妊娠女性的胎盘组成；第2组包括25例感染3型副流感病毒的女性的胎盘；第3组由25例在妊娠中期发生混合性呼吸道病毒感染（3型副流感病毒与甲型流感病毒（H3N2）同时感染）的女性的胎盘组成。使用置于显微镜目镜（放大倍数15×20）中的方形多面立体测量网格，在苏木精和伊红染色的组织切片上测定胎盘重量及其形态学参数。
与第2组相比，第3组胎盘重量减轻，同时间质、绒毛周围和间质中的纤维蛋白样物质、假坏死、钙化、中间未成熟绒毛、小无血管绒毛增加，绒毛间隙出血，循环床体积减小。
妊娠中期女性发生混合性病毒性呼吸道感染对胎盘形成的负面影响更为明显。
