Kumar Gurinder, AlIsmaili Zubaida, Ilyas Sadia Hafez, Ayyash Bakar Mustafa, Tawfik Eslam, AlMasri Omar, Al Hadhrami Hanan, Al Yafei Zain, El Ghazali Gehad, AlKhasawneh Eihab
Division of Pediatric Nephrology, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.
Histocompatibility and Immunology Laboratory, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.
Pediatr Transplant. 2019 Nov;23(7):e13566. doi: 10.1111/petr.13566. Epub 2019 Aug 13.
Renal transplantation is the treatment of choice for ESRD in children. It is associated with better quality of life, growth of children, and improved long-term survival. The aim of the study was to evaluate the outcomes of pediatric renal transplantation at a tertiary care center in UAE. A retrospective chart review was undertaken for all the pediatric renal transplants performed at Sheikh Khalifa Medical City, Abu Dhabi, UAE, over the past 9 years. The study evaluated the demographic data, outcomes, and complications of pediatric renal transplantation. The post-transplantation outcomes including surgical complications, documented infections, graft rejection, graft and patient survival, effect on growth, and eGFR were reviewed. Between 2010 and 2018, 30 pediatric patients underwent renal transplantation. The follow-up period ranged from 1 to 9 years with a mean of 3.3 years. The mean age of the patients at the time of transplant was 9.8 years, and 56.7% were males. Prior to the transplantation, the majority of the recipients were on peritoneal dialysis (70.0%). Main source of renal donation at our center was from LRD, chiefly from parents. Patient survival at 1 and 5 years was 100% and 96.7%, respectively. Graft survival at 1 and 5 years was 96.7% and 83.3%, respectively. During the 9-year follow-up period, 5 (16.7%) recipients experienced rejection episode. This study demonstrates that during 5-year period, pediatric kidney transplantation program has achieved optimal patient (96.7%) and graft (83.3%) survival rates and is comparable to well-established centers.
肾移植是儿童终末期肾病的首选治疗方法。它与更好的生活质量、儿童生长发育以及改善长期生存率相关。本研究的目的是评估阿联酋一家三级医疗中心的小儿肾移植结果。对过去9年在阿联酋阿布扎比谢赫哈利法医疗城进行的所有小儿肾移植进行了回顾性病历审查。该研究评估了小儿肾移植的人口统计学数据、结果和并发症。回顾了移植后的结果，包括手术并发症、记录的感染、移植排斥反应、移植物和患者生存率、对生长的影响以及估算肾小球滤过率（eGFR）。2010年至2018年期间，30例小儿患者接受了肾移植。随访期为1至9年，平均为3.3年。移植时患者的平均年龄为9.8岁，男性占56.7%。移植前，大多数受者接受腹膜透析（70.0%）。我们中心肾脏捐赠的主要来源是活体亲属捐赠（LRD），主要来自父母。1年和5年时的患者生存率分别为100%和96.7%。1年和5年时的移植物生存率分别为96.7%和83.3%。在9年的随访期内，5例（16.7%）受者经历了排斥反应。这项研究表明，在5年期间，小儿肾移植项目已实现了最佳的患者（96.7%）和移植物（83.3%）生存率，并且与成熟的中心相当。
