无创心肌做功指数与收缩和舒张功能主要参数的相关性：EACVI NORRE 研究结果。
Correlation between non-invasive myocardial work indices and main parameters of systolic and diastolic function: results from the EACVI NORRE study.
机构信息
Department of Cardiology, University of Liège Hospital, GIGA Cardiovascular Sciences, Heart Valve Clinic, CHU du Sart Tilman, Domaine Universitaire du Sart Tilman, Batiment B35, 4000 Liège, Belgium.
Department of Clinical Laboratory, Mie University Hospital, Mie, 2-174 Edobashi, 514-8507 Tsu, Japan.
出版信息
Eur Heart J Cardiovasc Imaging. 2020 May 1;21(5):533-541. doi: 10.1093/ehjci/jez203.
AIMS
The present study sought to evaluate the correlation between indices of non-invasive myocardial work (MW) and left ventricle (LV) size, traditional and advanced parameters of LV systolic and diastolic function by 2D echocardiography (2DE).
METHODS AND RESULTS
A total of 226 (85 men, mean age: 45 ± 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from LV pressure-strain loops using custom software. Peak LV pressure was estimated non-invasively from brachial artery cuff pressure. LV size, parameters of systolic and diastolic function and ventricular-arterial coupling were measured by echocardiography. As advanced indices of myocardial performance, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) were obtained. On multivariable analysis, GWI was significantly correlated with GLS (standardized beta-coefficient = -0.23, P < 0.001), ejection fraction (EF) (standardized beta-coefficient = 0.15, P = 0.02), systolic blood pressure (SBP) (standardized beta-coefficient = 0.56, P < 0.001) and GRS (standardized beta-coefficient = 0.19, P = 0.004), while GCW was correlated with GLS (standardized beta-coefficient = -0.55, P < 0.001), SBP (standardized beta-coefficient = 0.71, P < 0.001), GRS (standardized beta-coefficient = 0.11, P = 0.02), and GCS (standardized beta-coefficient = -0.10, P = 0.01). GWE was directly correlated with EF and inversely correlated with Tei index (standardized beta-coefficient = 0.18, P = 0.009 and standardized beta-coefficient = -0.20, P = 0.004, respectively), the opposite occurred for GWW (standardized beta-coefficient =--0.14, P = 0.03 and standardized beta-coefficient = 0.17, P = 0.01, respectively).
CONCLUSION
The non-invasive MW indices show a good correlation with traditional 2DE parameters of myocardial systolic function and myocardial strain.
目的
本研究旨在通过二维超声心动图（2DE）评估无创心肌做功（MW）指数与左心室（LV）大小、LV 收缩和舒张功能的传统和先进参数之间的相关性。
方法和结果
共有 226 名（85 名男性，平均年龄：45±13 岁）健康受试者在 NORRE 研究的 22 个合作机构中被纳入研究。使用定制软件从 LV 压力-应变环中估算出整体做功指数（GWI）、整体构造成功率（GCW）、整体做功浪费（GWW）和整体做功效率（GWE）。LV 压力通过肱动脉袖带压力无创估计。通过超声心动图测量 LV 大小、收缩和舒张功能参数以及心室-动脉偶联。获得整体纵向应变（GLS）、整体周向应变（GCS）和整体径向应变（GRS）作为心肌功能的先进指数。多元分析显示，GWI 与 GLS（标准化β系数=-0.23，P<0.001）、射血分数（EF）（标准化β系数=0.15，P=0.02）、收缩压（SBP）（标准化β系数=0.56，P<0.001）和 GRS（标准化β系数=0.19，P=0.004）显著相关，而 GCW 与 GLS（标准化β系数=-0.55，P<0.001）、SBP（标准化β系数=0.71，P<0.001）、GRS（标准化β系数=0.11，P=0.02）和 GCS（标准化β系数=-0.10，P=0.01）相关。GWE 与 EF 呈正相关，与 Tei 指数呈负相关（标准化β系数=0.18，P=0.009 和标准化β系数=-0.20，P=0.004），而 GWW 则相反（标准化β系数=-0.14，P=0.03 和标准化β系数=0.17，P=0.01）。
结论
无创 MW 指数与传统 2DE 心肌收缩功能和心肌应变参数具有良好的相关性。
Zotero 插件