Lehrstuhl für Funktionelle Genomforschung der Mikroorganismen, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, D-40225 Düsseldorf, Germany.
Biol Chem. 2019 Sep 25;400(10):1323-1334. doi: 10.1515/hsz-2019-0187.
The eukaryotic plasma membrane (PM) consists largely of phospholipids and proteins, and separates the intracellular compartments from the extracellular space. It also serves as a signaling platform for cell-to-cell communication and an interaction platform for the molecular crosstalk between pathogens and their target cells. Much research has been done to elucidate the interactions between pathogens and host membrane proteins. However, little is known about the interactions between pathogens and membrane phospholipids, although reports have described a contribution of phospholipids to cell recognition and/or invasion during early infection by diverse pathogens. Thus, during adhesion to the host cell, the obligate intracellular bacterial pathogens Chlamydia spp., the facultative intracellular pathogen Helicobacter pylori and the facultative aerobic pathogen Vibrio parahaemolyticus, interact with exofacial phospholipids. This review focuses on several prominent instances of pathogen interaction with host-cell phospholipids.
真核细胞质膜（PM）主要由磷脂和蛋白质组成，将细胞内隔室与细胞外空间隔开。它还是细胞间通讯的信号平台和病原体与其靶细胞之间分子串扰的相互作用平台。已经进行了大量研究来阐明病原体与宿主膜蛋白之间的相互作用。然而，尽管有报道描述了磷脂在多种病原体早期感染过程中对细胞识别和/或入侵的贡献，但对于病原体与膜磷脂之间的相互作用却知之甚少。因此，在与宿主细胞粘附期间，专性细胞内细菌病原体沙眼衣原体、兼性细胞内病原体幽门螺杆菌和兼性需氧病原体副溶血性弧菌与外表面磷脂相互作用。本文重点介绍了几种病原体与宿主细胞磷脂相互作用的突出实例。
