Pokorová Šárka, Fabian Pavel
Klin Onkol. 2019 Summer;32(Supplementum2):92-96. doi: 10.14735/amko2019S92.
Gastrointestinal polyposes and Lynch syndrome are a group of heterogenous hereditary tumor syndromes associated with an increased risk of developing colorectal carcinoma and other malignancies. Typical early manifestations of gastrointestinal polyposes include multiple polyps in the gastrointestinal tract. Early recognition of these syndromes enables patients carrying a pathogenic mutation to undergo screening and to instigate precautions to minimize the risk of developing tumors. In some cases, gastrointestinal lesions could be an early indicator of tumor syndrome and histopathologic examination could lead to a recommendation for genetic testing of patients and their families. Supported by Ministry of Health, Czech Republic - Conceptual Development of Research Organization (MMCI, 00209805). The authors declare they have no potential conflicts of interest concerning drugs, products,or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers. Submitted: 16. 4. 2019 Accepted: 6. 6. 2019.
胃肠道息肉病和林奇综合征是一组异质性遗传性肿瘤综合征，与患结直肠癌和其他恶性肿瘤的风险增加相关。胃肠道息肉病的典型早期表现包括胃肠道内出现多个息肉。早期识别这些综合征能使携带致病突变的患者接受筛查并采取预防措施，以将患肿瘤的风险降至最低。在某些情况下，胃肠道病变可能是肿瘤综合征的早期指标，组织病理学检查可能会建议对患者及其家属进行基因检测。由捷克共和国卫生部资助——研究组织的概念发展（摩拉维亚-西里西亚癌症中心，00209805）。作者声明他们在研究中使用的药物、产品或服务方面不存在潜在利益冲突。编辑委员会声明该手稿符合国际医学期刊编辑委员会对生物医学论文的建议。提交日期：2019年4月16日；接受日期：2019年6月6日。
