1 University of Oregon, Eugene, USA.
2 The University of Melbourne, Victoria, Australia.
J Atten Disord. 2019 Sep;23(11):1346-1355. doi: 10.1177/1087054716682336. Epub 2016 Dec 19.
Investigate neurodevelopmental trajectories related to attention/hyperactivity problems (AP) in a community sample of adolescents and whether these trajectories predict later-emerging health risk behaviors. One hundred sixty-six participants underwent up to three magnetic resonance imaging (MRI) scans ( = 367) between 11 and 20 years of age. AP were measured during early adolescence using the Child Behaviour Checklist, and engagement in risk behaviors was measured during late adolescence using the "DRIVE" survey (i.e., driving risks) and items assessing alcohol-harms. Greater AP scores during early adolescence were related to less reduction over time of left dorsal prefrontal, left ventrolateral prefrontal, and right orbitofrontal thickness. Less thinning of the orbitofrontal cortex was related to greater driving-related risk behaviors at late adolescence. Findings highlight altered neurodevelopmental trajectories in adolescents with AP. Furthermore, altered orbitofrontal development was related to later-emerging driving-related risk, and this neurobiological change mediated the association between attention problems and risk behaviors.
研究注意力/多动问题（AP）相关的神经发育轨迹在青少年社区样本中，以及这些轨迹是否预测后来出现的健康风险行为。166 名参与者在 11 至 20 岁之间接受了多达 3 次磁共振成像（MRI）扫描（= 367）。在青少年早期使用儿童行为检查表测量 AP，在青少年晚期使用“DRIVE”调查（即驾驶风险）和评估酒精危害的项目测量风险行为的参与度。青少年早期的 AP 评分较高与左背外侧前额叶、左腹外侧前额叶和右眶额皮质厚度随时间减少较少有关。眶额皮层变薄与青少年晚期与驾驶相关的风险行为增加有关。研究结果强调了注意力缺陷多动障碍青少年的神经发育轨迹改变。此外，眶额叶发育的改变与后来出现的与驾驶相关的风险有关，这种神经生物学变化介导了注意力问题和风险行为之间的关联。
