Cancer Discov. 2019 Oct;9(10):OF5. doi: 10.1158/2159-8290.CD-ND2019-009. Epub 2019 Aug 13.
Multiple companies are pursuing mRNA-based medicines that harness the body's protein-making machinery to transform lab-synthesized nucleotides into cancer-associated antigens, in the case of vaccines, or immune-stimulating molecules, in the case of therapeutics. Several candidates from BioNTech and Moderna have shown promise in early-stage testing.
多家公司正在研发基于 mRNA 的药物,利用人体的蛋白质制造机制将实验室合成的核苷酸转化为疫苗中的癌症相关抗原,或治疗药物中的免疫刺激分子。BioNTech 和 Moderna 的几种候选药物在早期测试中显示出了希望。