治疗套餐时间对接受手术和术后（放化疗）治疗的 HPV+口咽鳞状细胞癌的局部区域控制的影响。
The impact of treatment package time on locoregional control for HPV+ oropharyngeal squamous cell carcinoma treated with surgery and postoperative (chemo)radiation.
机构信息
Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Otorhinolaryngology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
出版信息
Head Neck. 2019 Nov;41(11):3858-3868. doi: 10.1002/hed.25914. Epub 2019 Aug 14.
BACKGROUND
For patients with head and neck squamous cell carcinoma (SCC) undergoing surgery followed by postoperative radiotherapy (PORT), time from surgery to completion of adjuvant therapy, "package time" impacts locoregional control (LRC). However, the significance of package time in HPV+ oropharyngeal SCC (OPSCC) is unknown.
METHODS
We examined patients undergoing TORS resection with PORT for HPV+ OPSCC from January 2010 to December 2015 with ≥18 months follow-up (n = 267). A cutoff of 15 weeks was used to delineate patients into short and long package time groups. LRC loss was defined as any recurrence after surgery.
RESULTS
Prolonged package time >15 weeks was associated with inferior LRC in this HPV+ OPSCC cohort, driven primarily by interval from surgery to PORT initiation. Multivariate analysis showed that package time and T classification are both independently associated with LRC.
CONCLUSIONS
Among HPV+ OPSCC, prolongation of package time appears to compromise LRC, but not survival.
背景
对于接受手术和术后放疗（PORT）的头颈部鳞状细胞癌（SCC）患者，从手术到辅助治疗完成的时间（“套餐时间”）会影响局部区域控制（LRC）。然而，在 HPV+口咽 SCC（OPSCC）中，套餐时间的意义尚不清楚。
方法
我们检查了 2010 年 1 月至 2015 年 12 月期间接受 TORS 切除术和 PORT 治疗的 HPV+ OPSCC 患者，随访时间≥18 个月（n=267）。使用 15 周的时间作为界限，将患者分为短套餐时间组和长套餐时间组。LRC 损失定义为手术后的任何复发。
结果
在 HPV+ OPSCC 队列中，套餐时间延长>15 周与较低的 LRC 相关，主要是由于手术与 PORT 开始之间的时间间隔。多因素分析表明，套餐时间和 T 分类都与 LRC 独立相关。
结论
在 HPV+ OPSCC 中，套餐时间延长似乎会影响 LRC，但不会影响生存。
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