Sánchez-Canteli Mario, García-Pedrero Juana M, Rodrigo Juan P
Department of Otolaryngology, Hospital Universitario de San Agustín (Avilés) and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011, Oviedo, Spain.
Ciber de Cáncer, CIBERONC, 28029, Madrid, Spain.
Eur Arch Otorhinolaryngol. 2025 Jun 21. doi: 10.1007/s00405-025-09517-3.
The impact of key treatment intervals on head and neck squamous cell carcinoma (HNSCC) survival remains unclear.
This systematic review and meta-analysis, conducted following PRISMA guidelines, assessed 22 cohort studies including 322,569 patients. The mean threshold for prolonged total treatment package time (TPT) was 95.21 days, while for surgery-to-postoperative radiotherapy (S-PORT), it was 6.9 weeks.
Both prolonged TPT and S-PORT intervals were significantly associated with reduced survival (TPT: HR = 1.25; S-PORT: HR = 1.03; p < 0.0001). However, the negative impact of extended TPT was more pronounced compared to S-PORT delays.
These findings suggest that minimizing TPT delays is critical for optimizing HNSCC outcomes. However, substantial heterogeneity across studies limits the generalizability of results. Further research is needed to establish standardized treatment timelines and improve survival rates in HNSCC patients.
关键治疗间隔对头颈部鳞状细胞癌（HNSCC）生存率的影响仍不明确。
本系统评价和荟萃分析遵循PRISMA指南进行，评估了22项队列研究，共322,569例患者。延长总治疗时间（TPT）的平均阈值为95.21天，而手术至术后放疗（S-PORT）的平均阈值为6.9周。
延长TPT和S-PORT间隔均与生存率降低显著相关（TPT：HR = 1.25；S-PORT：HR = 1.03；p < 0.0001）。然而，与S-PORT延迟相比，延长TPT的负面影响更为明显。
这些发现表明，尽量减少TPT延迟对于优化HNSCC治疗结果至关重要。然而，各研究之间存在的显著异质性限制了结果的普遍性。需要进一步研究以建立标准化治疗时间表并提高HNSCC患者的生存率。
