Zou Dazhong, Wu Chengwei, Miao Jixuan, Shao Qing, Huang Wenlong, Huang Jianda, Wu Guihua, Zhang Qing
Department of Ultrasonography, The Jiangyin Clinical College of Xuzhou Medical University, Jiangyin, China.
Department of Ultrasonography, Suzhou Wuzhong People's Hospital, Suzhou, China.
Genet Test Mol Biomarkers. 2019 Sep;23(9):681-687. doi: 10.1089/gtmb.2019.0028. Epub 2019 Aug 14.
To compare fine-needle aspiration cytology (FNAC) with imprinted gene detection in the differential diagnosis of benign and malignant thyroid nodules. A total of 34 patients (35 cases of thyroid nodules) were examined using fine-needle puncture biopsy under ultrasound guidance, and the biopsy tissues were examined by cytologic examination and imprinted gene detection. Combined with postoperative pathology and follow-up results, the diagnostic value and consistency of the two methods were analyzed and compared. The detection of benign and malignant thyroid nodules by ARHI imprinted gene had a high consistency with FNAC, and ARHI imprinted gene detection had a higher detection rate, sensitivity, and accuracy. Imprinted gene detection has high accuracy and sensitivity in the differential diagnosis of benign and malignant thyroid nodules. It provides a scientific reference for clinical treatment and should be incorporated into diagnostic protocols for thyroid tumor.
比较细针穿刺细胞学检查（FNAC）与印记基因检测在甲状腺良恶性结节鉴别诊断中的应用。对34例患者（35个甲状腺结节病例）在超声引导下进行细针穿刺活检，对活检组织进行细胞学检查和印记基因检测。结合术后病理及随访结果，分析比较两种方法的诊断价值及一致性。ARHI印记基因对甲状腺良恶性结节的检测与FNAC具有较高的一致性，且ARHI印记基因检测具有更高的检出率、灵敏度和准确性。印记基因检测在甲状腺良恶性结节的鉴别诊断中具有较高的准确性和灵敏度。为临床治疗提供了科学参考，应纳入甲状腺肿瘤的诊断方案。
