钴(II)催化通过 C-N 键活化的脂肪族伯胺的烷氧基羰基化反应。
Cobalt(II)-Catalyzed Alkoxycarbonylation of Aliphatic Amines via C-N Bond Activation.
机构信息
Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou 310018, People's Republic of China.
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock, Germany.
出版信息
Org Lett. 2019 Sep 6;21(17):6919-6923. doi: 10.1021/acs.orglett.9b02534. Epub 2019 Aug 14.
The first cobalt-catalyzed deaminative alkoxycarbonylation reaction was described for the conversion of readily available primary alkyl amines to synthetically versatile esters with moderate to high yields. This transformation shows good functional group compatibility and can serve as a powerful tool for the modification of alkyl amine-containing complex natural products and drug molecules.
首次报道了钴催化的脱氨烷氧基羰基化反应，该反应可将易得的伯烷基胺转化为具有中等至较高收率的合成多功能酯。这种转化具有良好的官能团兼容性，可作为修饰含烷基胺的复杂天然产物和药物分子的有力工具。
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