Servicio de Medicina Interna, Hospital Universitario de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España.
Servicio de Medicina Interna, Hospital Universitario de Bellvitge, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España.
Med Clin (Barc). 2019 Nov 29;153(10):402-409. doi: 10.1016/j.medcli.2019.06.006. Epub 2019 Aug 12.
Heart failure (HF) is a chronic disease with significant morbidity and mortality. Substantial haemodynamic changes such as hypoperfusion and intestinal congestion can alter the composition of the intestinal microbiota in patients with HF. The aim of this systematic review is to evaluate the influence of bowel function in patients with HF and the possible role of the intestinal microbiota in the development and evolution of the latter. Eleven studies were included in the review. These studies seem to confirm that HF patients present with substantial abnormalities in the composition of their intestinal microbiota. Trimethylamine N-oxide is identified as a key mediator between the alterations in the intestinal microbiota and HF and correlates with worse prognosis in HF patients. In conclusion, patients with HF present with frequent abnormalities in the characteristics of their intestinal microbiota, which may play a role in the prognosis of the disease.
心力衰竭（HF）是一种具有显著发病率和死亡率的慢性疾病。大量血流动力学变化，如灌注不足和肠道淤血，可改变 HF 患者的肠道微生物群组成。本系统评价的目的是评估 HF 患者的肠道功能以及肠道微生物群在后者发生和发展中的可能作用。综述纳入了 11 项研究。这些研究似乎证实 HF 患者的肠道微生物群组成存在显著异常。三甲胺 N-氧化物被确定为肠道微生物群改变与 HF 之间的关键介质，与 HF 患者的预后较差相关。总之，HF 患者的肠道微生物群特征常出现异常，这可能与疾病的预后有关。
