光诱导合成氟代二苯并[b,e]氮杂卓：通过自由基引发的环化反应。
Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization.
机构信息
Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province and Chemistry and Chemical Engineering Laboratory of Guangdong Province, Shantou University, Guangdong 515063, P. R. China.
出版信息
Chem Commun (Camb). 2019 Sep 10;55(73):10848-10851. doi: 10.1039/c9cc04977k.
A simple, mild and efficient approach to access fluorinated dibenz[b,e]azepines via visible-light photoredox catalysis is presented. Inexpensive and commercially available fluoroalkyl anhydrides in concert with pyridine N-oxide are employed as the source of the fluoroalkyl radicals. A one-pot process involving the trifluoroacetylation of unprotected secondary benzyl amines followed by radical cyclization could also afford the desired fluorinated dibenz[b,e]azepines.
本文报道了一种通过可见光光氧化还原催化方法来构建氟化二苯并[b,e]氮杂卓的简洁、温和、高效的方法。廉价且市售的氟烷基酸酐与吡啶 N-氧化物共同作为氟烷基自由基的来源。一锅法反应包括未保护的仲苄胺的三氟乙酰化反应，随后进行自由基环化反应，也可以得到所需的氟化二苯并[b,e]氮杂卓。
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