Sun Ke-Meng, Sang Wei, Xu Lin-Yan, Yan Dong-Mei, Song Xu-Guang, Sun Cai, Sun Xiao-Kun, Xu Kai-Lin
Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.
Institute of Hematology,Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Aug;27(4):1118-1122. doi: 10.19746/j.cnki.issn.1009-2137.2019.04.020.
To explore the significance of lymphocyte to monocyte ratio (LMR) in the disease progress of primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL).
The clinical data of 43 patients diagnosed as PGI-DLBCL in our hospital from January 2011 to December 2015 were collected, and the disease progress was followed up.
According to the ROC curve, the threshold value of LMR for 2 years PFS (%) of PGI-DLBCL patients was 2.6. Unvariate analysis showed that LMR (P＜0.05), large enclosed mass lesion (P＜0.01) and IPI (P＜0.05) were prognostic factors affecting PFS, the COX regression model multivariate analysis showed that LMR＜2.6 [ (risk ratio (RR)=3.083, 95%CI 1.828-8.313, P＜0.01], and large enclosed mass lesions (RR=2.718, 95%CI 1.339-6.424, P＜0.05) were the independent adverse prognostic factor for two years PFS.
Both LMR＜2.6 and large enclosed mass lesions relate with the progress of PGI-DLBCL.
探讨淋巴细胞与单核细胞比值（LMR）在原发性胃肠道弥漫性大B细胞淋巴瘤（PGI-DLBCL）疾病进展中的意义。
收集2011年1月至2015年12月在我院确诊为PGI-DLBCL的43例患者的临床资料，并对疾病进展进行随访。
根据ROC曲线，PGI-DLBCL患者2年无进展生存率（PFS）的LMR阈值为2.6。单因素分析显示，LMR（P＜0.05）、大的包块病变（P＜0.01）和国际预后指数（IPI）（P＜0.05）是影响PFS的预后因素，COX回归模型多因素分析显示，LMR＜2.6[风险比（RR）=3.083，95%可信区间1.828-8.313，P＜0.01]和大的包块病变（RR=2.718，95%可信区间1.339-6.424，P＜0.05）是2年PFS的独立不良预后因素。
LMR＜2.6和大的包块病变均与PGI-DLBCL的进展有关。
