D'Angelo G, Calvano D, Giardini C
Presidio Ospedaliero di Somma Lombardo, U.S.S.L. n. 6 - Gallarate, Varese.
Minerva Med. 1988 Oct;79(10):853-7.
Morphofunctional alterations to the platelets in myeloproliferative disorders (MPD), conditions featuring clonal rearrangement of the haemopoietic stem-cell, were examined. These platelet anomalies including morphological alterations, acquired storage pool disease, membrane alterations, altered arachidonic acid metabolism and structural alterations to the von Willebrand factor may cause thromboembolisms or haemorrhages that are responsible for a significant incidence of morbidity and mortality. In contrast the reduced mitogenic activity of the platelets may be of significant prognostic value since it proves the anomalous transformation of the megakaryocytic clone. The main in vivo and in vitro tests (bleeding time and the study of platelet aggregation) were investigate as indicators of platelet function. Unfortunately, these tests proved of little use for the early diagnosis of haemorrhage or thromboembolism in MPD.
对骨髓增殖性疾病（MPD）中的血小板形态功能改变进行了检查，MPD是以造血干细胞克隆重排为特征的病症。这些血小板异常包括形态改变、获得性储存池病、膜改变、花生四烯酸代谢改变以及血管性血友病因子的结构改变，可能会导致血栓栓塞或出血，这在相当程度上导致了发病率和死亡率。相比之下，血小板有丝分裂活性降低可能具有重要的预后价值，因为这证明了巨核细胞克隆的异常转化。研究了主要的体内和体外试验（出血时间和血小板聚集研究）作为血小板功能的指标。不幸的是，这些试验对于MPD中出血或血栓栓塞的早期诊断几乎没有用处。
