Kreiner D, Droesch K, Navot D, Scott R, Rosenwaks Z
Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk.
Obstet Gynecol. 1988 Dec;72(6):926-8. doi: 10.1097/00006250-198812000-00024.
To determine the fertility potential of patients with apparent ovarian failure, a retrospective analysis of 86 ovarian failure patients in the Norfolk oocyte donation program was performed. None of the 23 patients with primary ovarian failure ovulated. Seven of 63 (11.1%) with secondary ovarian failure did ovulate, and three of 63 (4.8%) conceived and delivered normal, healthy infants. Of patients whose etiology for ovarian failure was partial ovarian resection or chemotherapy, the ovulation rate and pregnancy rate were 30.8 and 15.4%, respectively, compared with 5.0 and 1.7%, respectively, for the other patients with secondary ovarian failure. Serum estradiol and FSH obtained during hormone replacement were not predictive of the resumption of normal reproductive functions. Therefore, it is recommended that patients with secondary ovarian failure, especially in the better-prognosis group, be treated with a trial of estradiol replacement and have close monitoring for ovulation before oocyte donation.
为了确定明显卵巢功能衰竭患者的生育潜力，对诺福克卵母细胞捐赠项目中的86例卵巢功能衰竭患者进行了回顾性分析。23例原发性卵巢功能衰竭患者均未排卵。63例继发性卵巢功能衰竭患者中有7例（11.1%）排卵，63例中有3例（4.8%）成功受孕并分娩出正常、健康的婴儿。卵巢功能衰竭病因是部分卵巢切除或化疗的患者，其排卵率和妊娠率分别为30.8%和15.4%，而其他继发性卵巢功能衰竭患者的排卵率和妊娠率分别为5.0%和1.7%。激素替代治疗期间测得的血清雌二醇和促卵泡生成素不能预测正常生殖功能的恢复。因此，建议对继发性卵巢功能衰竭患者，尤其是预后较好的患者，进行雌二醇替代试验治疗，并在卵母细胞捐赠前密切监测排卵情况。
