Sarioglu Nurhan, Erel Fuat, Hismioğullari A Adil, Cevik Celalettin
Medicine Faculty, Department of Pulmonary Medicine, Balıkesir University, Balıkesir, Turkey.
Medicine Faculty, Department of Biochemistry, Balıkesir University, Balıkesir, Turkey.
Sleep Breath. 2020 Sep;24(3):835-840. doi: 10.1007/s11325-019-01909-0. Epub 2019 Aug 16.
A disintegrin and metalloproteinase with thrombospondin type-1 motifs (ADAMTS) proteinases have important roles in degradation/repairing of extracellular matrix (ECM). They are thought to play a key role in pathogenesis of many diseases. We aimed to investigate the association between ADAMTS 2, 3, and 14 (procollagen) and obstructive sleep apnea (OSA).
Eighty-six individuals who were suspected of OSA were included. All cases underwent polysomnography. Participants were divided into 3 groups according to apnea-hypopnea index (AHI): control (n = 22), mild-to-moderate OSA (n = 36), and severe OSA (n = 28). ADAMTS proteinases 2, 3, and 14 were analyzed in serum samples.
When compared with other groups, patients with severe OSA showed significantly higher body mass index (BMI) (p = 0.001), whereas they showed significantly lower ADAMTS 3 levels (p = 0.016). No difference was found between groups with respect to the levels ADAMTS 2 and 14. There was a negative relation between the levels of ADAMTS 3 and the severity of OSA (Kendall's tau = - 0.19, p = 0.021). The levels of ADAMTS 3 were also found to be positively correlated with minimum SpO (r = 0.31, p = 0.004) and negatively correlated with BMI, AHI, oxygen desaturation index (ODI), time duration with oxygen saturation < 90% (T90), and CRP (r = - 0.31 to - 0.49, p < 0.05). Multivariable regression analysis revealed that BMI (p = 0.013) and CRP levels (p = 0.005) were significantly associated with the levels of ADAMTS 3.
ADAMTS 3, one of the procollagen proteinases, was decreased in severe OSA. Lack of ADAMTS 3 proteinase may contribute to process of sleep apnea due to insufficient collagen syntheses.
含血小板反应蛋白基序的解聚素和金属蛋白酶（ADAMTS）蛋白酶在细胞外基质（ECM）的降解/修复中起重要作用。它们被认为在许多疾病的发病机制中起关键作用。我们旨在研究ADAMTS 2、3和14（前胶原）与阻塞性睡眠呼吸暂停（OSA）之间的关联。
纳入86名疑似OSA的个体。所有病例均接受多导睡眠图检查。参与者根据呼吸暂停低通气指数（AHI）分为3组：对照组（n = 22）、轻度至中度OSA组（n = 36）和重度OSA组（n = 28）。对血清样本中的ADAMTS蛋白酶2、3和14进行分析。
与其他组相比，重度OSA患者的体重指数（BMI）显著更高（p = 0.001），而他们的ADAMTS 3水平显著更低（p = 0.016）。ADAMTS 2和14水平在各组之间未发现差异。ADAMTS 3水平与OSA严重程度之间存在负相关（肯德尔tau系数 = -0.19，p = 0.021）。还发现ADAMTS 3水平与最低血氧饱和度（SpO）呈正相关（r = 0.31，p = 0.004），与BMI、AHI、氧饱和度下降指数（ODI）、血氧饱和度<90%的持续时间（T90）和CRP呈负相关（r = -0.31至-0.49，p < 0.05）。多变量回归分析显示，BMI（p = 0.013）和CRP水平（p = 0.005）与ADAMTS 3水平显著相关。
前胶原蛋白酶之一的ADAMTS 3在重度OSA中降低。ADAMTS 3蛋白酶的缺乏可能由于胶原蛋白合成不足而导致睡眠呼吸暂停过程。
