Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
IRCCS Orthopedic Institute Galeazzi, Milan, Italy.
Clin Chem Lab Med. 2019 Dec 18;58(1):11-17. doi: 10.1515/cclm-2019-0643.
The appropriate identification of bacterial infection is the basis for effective treatment and control of infective disease. Among this context, an emerging biomarker of infection is presepsin (PSP), recently described as early marker of different infections. PSP secretion has been shown to be associated with monocyte phagocytosis and plasmatic levels of PSP increase in response to bacterial infection and decrease after antibiotic treatment, therefore it can be considered a marker of activation of immune cell response towards an invading pathogen. Different methods have been developed to measure PSP and this review will briefly describe the different clinical fields of application of PSP, ranging from intensive care to neonatal infection, to orthopedic and pulmonary infection as well as fungal infections and cardiovascular infections.
准确识别细菌感染是有效治疗和控制感染性疾病的基础。在这种情况下，一种新出现的感染生物标志物是降钙素原前肽（PSP），它最近被描述为不同感染的早期标志物。已经表明，PSP 的分泌与单核细胞吞噬作用有关，并且 PSP 的血浆水平在细菌感染时增加，在抗生素治疗后降低，因此它可以被认为是免疫细胞对入侵病原体的反应激活的标志物。已经开发了不同的方法来测量 PSP，本综述将简要描述 PSP 的不同临床应用领域，从重症监护到新生儿感染，再到骨科和肺部感染以及真菌感染和心血管感染。
