Instituto de Ciencias Biológicas y Biomédicas del Sur (INBIOSUR), Universidad Nacional del Sur (UNS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, UNS, San Juan 670, B8000ICN, Bahía Blanca, Argentina.
Mol Cell Endocrinol. 2019 Dec 1;498:110543. doi: 10.1016/j.mce.2019.110543. Epub 2019 Aug 14.
In this work we tested the hypothesis whether progesterone (Pg) or the synthetic progestin medroxyprogesterone acetate (MPA) could be involved in the regulation of events involved in vascular remodeling. Results revealed an enhancement in the capillary-like tubes formation induced by both progestogens. Unlike MPA, Pg acts through VEGF, nitric oxide, PI3K and ERK1/2 signaling pathways. However, the MPA effect depends on platelet activation. Under stress conditions, the proangiogenic action of Pg and MPA was sustained. The progestogens exhibit the ability to prevent vascular smooth muscle cells (VSMC) osteogenic transdifferentiation. Besides this antiosteogenic action, on bone cells the progestogens induced osteoblast maturation and mineralization. The mechanism of action of both steroids on vascular and bone cells involves the participation of progesterone receptor. The data presented in this work provide evidence that the progestogens reduce osteogenic-like transdifferentiation of VSMC and promote angiogenesis with a slight different mechanism of action elicited by each steroid.
在这项工作中，我们检验了假设，即孕激素（Pg）或合成孕激素醋酸甲羟孕酮（MPA）是否可能参与调节血管重塑相关事件。结果显示，这两种孕激素都能增强毛细血管样管腔的形成。与 MPA 不同，Pg 通过 VEGF、一氧化氮、PI3K 和 ERK1/2 信号通路发挥作用。然而，MPA 的作用取决于血小板的激活。在应激条件下，Pg 和 MPA 的促血管生成作用得以维持。孕激素具有防止血管平滑肌细胞（VSMC）成骨转化的能力。除了这种抗骨生成作用外，孕激素还能诱导成骨细胞成熟和矿化。这两种甾体激素对血管和骨细胞的作用机制涉及孕激素受体的参与。本工作中提供的资料表明，孕激素可减少 VSMC 的成骨样转化，并促进血管生成，而每种甾体激素的作用机制略有不同。
