[第二阶段生物转化反应对多种化合物诱变作用水平影响的艾姆斯试验研究]

[Ames test study of the effect of 2nd-phase biotransformation reactions on the level of mutagenic action of a number of chemical compounds].

作者信息

Loknitskaia N N, Fonshteĭn L M

出版信息

Tsitol Genet. 1988 May-Jun;22(3):43-6.

Abstract

Introduction of cosubstrates for reactions of conjugation with the reduced glutathione, glucuronic acid and sulphate is shown to modify (increase or decrease) the level of mutagenic effect of thiophosphamide, nitrosomethylurea and DDDTDP on S. typhimurium TA 1950 or TA 1534.

摘要

已表明引入与还原型谷胱甘肽、葡萄糖醛酸和硫酸盐结合反应的共底物会改变（增加或降低）硫代磷酰胺、亚硝基甲基脲和滴滴涕对鼠伤寒沙门氏菌TA 1950或TA 1534的诱变效应水平。

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