Khaetskiĭ I K, Nikitchenko V V, Andrushchak L I, Khaetskaia V I, Pinchuk V G
Vopr Onkol. 1988;34(10):1224-31.
The experiments used rats with mammary tumors induced by intravenous injection of DMBA. The animals were treated with alternating courses of estrogen and anti-estrogen (tamoxifen). The former was given in combination with papaverin and low doses of vitamin A. This was followed by light and electron microscopic examination of breast tumors which revealed activation of cell differentiation and tissue-specific function. The death of cells (active autolysis) was similar to one taking place in the course of physiologic involution of the organ but it was unlike liquefying and coagulation necrotic processes usually occurring in tumor.
实验使用通过静脉注射二甲基苯蒽诱导产生乳腺肿瘤的大鼠。这些动物接受雌激素和抗雌激素（他莫昔芬）交替疗程的治疗。前者与罂粟碱和低剂量维生素A联合使用。随后对乳腺肿瘤进行光镜和电镜检查，结果显示细胞分化和组织特异性功能被激活。细胞死亡（主动自溶）类似于该器官生理退化过程中发生的情况，但与肿瘤中通常发生的液化和凝固性坏死过程不同。
