Simovic Isidora, Castaño-Rodríguez Natalia, Kaakoush Nadeem O
School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, NSW 2052, Australia.
School of Medical Sciences, UNSW, Sydney, NSW 2052, Australia.
Trends Cancer. 2019 Aug;5(8):463-466. doi: 10.1016/j.trecan.2019.06.002. Epub 2019 Jun 28.
Opioid-binding protein/cell adhesion molecule (OPCML) is expressed in many tissues and localizes to the plasma membrane. It is a putative tumor suppressor that acts on receptor tyrosine kinases (RTKs), influencing cell cycle arrest, apoptosis, and migration. Its expression is silenced epigenetically in cancer, inferring potential diagnostic, prognostic, and therapeutic roles.
阿片样物质结合蛋白/细胞粘附分子（OPCML）在许多组织中表达，并定位于质膜。它是一种假定的肿瘤抑制因子，作用于受体酪氨酸激酶（RTK），影响细胞周期停滞、凋亡和迁移。其表达在癌症中通过表观遗传沉默，提示其具有潜在的诊断、预后和治疗作用。
