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Safety Report of TAS-102 in a Patient With Reduced DPD Activity.

作者信息

Bolzacchini Elena, Luchena Giovanna, Giordano Monica

机构信息

Department of Oncology, Ospedale Sant'Anna, Como, Italy.

Department of Oncology, Ospedale Sant'Anna, Como, Italy.

出版信息

Clin Colorectal Cancer. 2019 Dec;18(4):310-312. doi: 10.1016/j.clcc.2019.07.008. Epub 2019 Jul 29.

DOI:10.1016/j.clcc.2019.07.008
PMID:31421985
Abstract
摘要

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Genotyping of a family with a novel deleterious DPYD mutation supports the pretherapeutic screening of DPD deficiency with dihydrouracil/uracil ratio.对一个具有新型有害 DPYD 突变的家系进行基因分型，支持用二氢尿嘧啶/尿嘧啶比值进行 DPD 缺乏症的治疗前筛查。
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引用本文的文献

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Efficacy and Safety of Trifluridine/Tipiracil-Containing Combinations in Colorectal Cancer and Other Advanced Solid Tumors: A Systematic Review.含曲氟尿苷/替匹嘧啶的联合化疗方案在结直肠癌及其他晚期实体瘤中的疗效与安全性：一项系统评价
Oncologist. 2024 May 3;29(5):e601-e615. doi: 10.1093/oncolo/oyae007.
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Tas-102 for Refractory Metastatic Colorectal Cancer: A Multicenter Retrospective Cohort Study.TAS-102用于难治性转移性结直肠癌：一项多中心回顾性队列研究。
Cancers (Basel). 2023 Jul 2;15(13):3465. doi: 10.3390/cancers15133465.
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Dihydropyrimidine dehydrogenase (DPD) polymorphisms knocking on the door.
二氢嘧啶脱氢酶（DPD）多态性敲响了警钟。
Ecancermedicalscience. 2022 Jan 17;16:1344. doi: 10.3332/ecancer.2022.1344. eCollection 2022.
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Issues and limitations of available biomarkers for fluoropyrimidine-based chemotherapy toxicity, a narrative review of the literature.氟嘧啶类化疗毒性的现有生物标志物的问题和局限性：文献综述的叙述性评价。
ESMO Open. 2021 Jun;6(3):100125. doi: 10.1016/j.esmoop.2021.100125. Epub 2021 Apr 23.