雌激素治疗对前列腺癌患者睾丸促性腺激素受体的影响。

Effect of estrogen treatment on testicular gonadotropin receptors in prostatic cancer patients.

作者信息

Namiki M, Kitamura M, Nonomura N, Sugao H, Nakamura M, Okuyama A, Sonoda T, Matsumoto K

机构信息

Department of Urology and Pathology, Osaka University Medical School, Japan.

出版信息

Arch Androl. 1987;19(3):249-52. doi: 10.3109/01485018708986824.

DOI:10.3109/01485018708986824

PMID:3142377

Abstract

Effects of estrogen treatment on testicular human chorionic gonadotropin (hCG) and follicle-stimulating hormone (FSH) receptors in man were investigated. Ten patients (aged 58 to 75, mean 67 years) with prostatic cancer were treated with diethylstilbestrol diphosphate (DESDP) (300 mg daily, oral administration). They were divided into two groups: 5 of them (aged 58 to 74, mean 67 years) were orchiectomized after 7 days of treatment and the remainder (aged 60-75, mean 67 years) after 6 months of treatment. hCG and FSH receptors in the resected testes of each group were measured and compared with those of age-matched prostatic cancer patients without any treatment (controls). After 7 days and 6 months of DESDP treatment, the number of hCG receptors decreased to approximately 53% and 24%, respectively, of that of the controls. FSH receptors in the testes of the patients treated with DESDP did not differ significantly from those of the controls.

摘要

研究了雌激素治疗对男性睾丸人绒毛膜促性腺激素（hCG）和促卵泡激素（FSH）受体的影响。10例前列腺癌患者（年龄58至75岁，平均67岁）接受己烯雌酚二磷酸酯（DESDP）治疗（每日300mg，口服）。他们被分为两组：其中5例（年龄58至74岁，平均67岁）在治疗7天后接受睾丸切除术，其余（年龄60 - 75岁，平均67岁）在治疗6个月后接受睾丸切除术。测量每组切除睾丸中的hCG和FSH受体，并与未接受任何治疗的年龄匹配的前列腺癌患者（对照组）的受体进行比较。DESDP治疗7天和6个月后，hCG受体数量分别降至对照组的约53%和24%。接受DESDP治疗患者睾丸中的FSH受体与对照组相比无显著差异。