Lacolley P, Pannier B, Lévy B, Safar M
Centre de diagnostic, hôpital Broussais, Paris.
Arch Mal Coeur Vaiss. 1988 Jun;81 Spec No:55-8.
Three groups of 11 male subjects with the same mean age were studied: normotensives (group I), patients with sustained essential hypertension (group II) and patients with borderline hypertension (group III). M-mode echocardiography provided a measure of aortic root systolic diameter (D) and left ventricular mass index (LVMi, g/m2). We have used a 4 MHz pulsed doppler velocity meter with spectral analysis to measure instantaneous ascending aortic blood velocity. Measurements values were averaged during 10 s and included: stroke volume (SV, cm3 = integrated velocity over one cardiac cycle.aortic cross sectional area (3.14D2/4)), cardiac output (CO, cm3 = SV.heart rate), systemic vascular resistance (SVR, mmHg/cm3.s-1 = MAP/co) and maximal aortic acceleration (MA, cm/s2). (Table: see text). Stroke volume and cardiac output were similar in three groups. SVR was higher in group II than in group I. The myocardial contractility appreciated from the maximal aortic acceleration (Bennett et al, Cardiovasc Res 1984; 18: 632-8) was increased in patients with borderline hypertension and remained within the normal range in patients with sustained essential hypertension despite and increase in cardiac mass.
对三组平均年龄相同的11名男性受试者进行了研究:血压正常者(第一组)、持续性原发性高血压患者(第二组)和临界高血压患者(第三组)。M型超声心动图测量了主动脉根部收缩期直径(D)和左心室质量指数(LVMi,g/m²)。我们使用带有频谱分析的4兆赫脉冲多普勒速度计来测量升主动脉瞬时血流速度。测量值在10秒内进行平均,包括:每搏输出量(SV,cm³ = 一个心动周期内的积分速度×主动脉横截面积(3.14D²/4))、心输出量(CO,cm³ = SV×心率)、全身血管阻力(SVR,mmHg/cm³·s⁻¹ = 平均动脉压/心输出量)和最大主动脉加速度(MA,cm/s²)。(表格:见正文)。三组的每搏输出量和心输出量相似。第二组的全身血管阻力高于第一组。临界高血压患者从最大主动脉加速度评估的心肌收缩力(Bennett等人,《心血管研究》1984年;18:632 - 8)增加,而持续性原发性高血压患者尽管心脏质量增加,但其心肌收缩力仍保持在正常范围内。