使用 SERS 流分离条在 5 分钟内检测唾液、血浆和全血中的可待因和芬太尼。
Detection of codeine and fentanyl in saliva, blood plasma and whole blood in 5-minutes using a SERS flow-separation strip.
机构信息
Real-Time Analyzers, Inc., 362 Industrial Park Rd, Unit 8, Middletown, CT 06457, USA.
出版信息
Analyst. 2019 Sep 9;144(18):5449-5454. doi: 10.1039/c9an01087d.
Abstract
A simple-to-use device to measure drugs in saliva, blood plasma, and whole blood for point-of-care analysis and treatment of overdose patients has been investigated. A rudimentary flow strip has been developed to separate opioids from these biofluids for analysis by surface-enhanced Raman spectroscopy (SERS). The strips are based on lateral flow assays, in which the antibodies have been substituted by SERS-active pads for detection. Samples of codeine and fentanyl, artificially added to these biofluids, were measured using the strips by a field-usable Raman spectrometer. We report measurement of these drugs in these biofluids from 0.5 to 5 μg mL-1 in 5 minutes. Calculated limits of detection for the spectra suggest that these drugs could be measured at 5 to 20 ng mL-1 with improvements in the strips' separation capability.
摘要
一种用于测量唾液、血浆和全血中药物的简单易用的设备，用于即时检测和治疗药物过量患者，已经过研究。已经开发出一种基本的流动条，用于通过表面增强拉曼光谱（SERS）分析将阿片类药物从这些生物流体中分离出来。这些条带基于侧流分析，其中抗体已被 SERS 活性垫代替用于检测。使用现场可用的拉曼光谱仪，通过条带测量了这些生物流体中人工添加的可待因和芬太尼的样本。我们报告了在 5 分钟内从 0.5 到 5μgmL-1 的这些药物在这些生物流体中的测量结果。计算出的光谱检测限表明，通过改进条带的分离能力，这些药物可以在 5 到 20ngmL-1 的范围内进行测量。
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