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[DSP 4是一种破坏去甲肾上腺素能神经末梢的神经毒性剂,它能选择性地提高猫的“预期性”]

[DSP 4, a neurotoxic agent that destroys noradrenergic endings, selectively increases "expectancy" in the cat].

作者信息

Tadjer D, Delagrange P, Bouyer J J, Durand C, Rougeul A

机构信息

Institut des Neurosciences, U.A. n. 1199, C.N.R.S., Université Pierre-et-Marie-Curie, Département de Neurophysiologie comparée, Paris.

出版信息

C R Acad Sci III. 1988;307(11):647-52.

PMID:3142644
Abstract

Cats were treated with DSP 4, a neurotoxic agent known to destroy central noradrenergic endings. A significant increase was subsequently noticed in the amount of time spent by the treated animals in an attitude of "expectancy", i.e. of motionless waiting for an "event to occur". They even developed this attitude when no such real situation existed. Concomitantly, an increase was noticed in the power of the 14 Hz electrocortical rhythms recorded over the somatic sensory cortex. These patterns, designated as "mu" rhythms, had previously been shown to characterize this particular type of attentive state. The present data tends to confirm our previous hypothesis, that immobile expectancy and its accompanying electrocortical pattern are under a noradrenergic inhibitory control.

摘要

猫被注射了DSP 4,一种已知会破坏中枢去甲肾上腺素能神经末梢的神经毒性剂。随后发现,接受治疗的动物以“期待”姿态(即静止不动等待“事件发生”)所花费的时间显著增加。即使在不存在这种实际情况时,它们也会出现这种姿态。与此同时,在躯体感觉皮层记录到的14赫兹脑电节律的功率有所增加。这些模式被称为“μ”节律,此前已被证明是这种特定类型的注意力状态的特征。目前的数据倾向于证实我们之前的假设,即静止不动的期待及其伴随的脑电模式受去甲肾上腺素能抑制控制。

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