γ干扰素对血小板衍生生长因子（PDGF）、表皮生长因子（EGF）和成纤维细胞生长因子（FGF）促有丝分裂活性的抑制作用。
Inhibition of mitogenic activity of PDGF, EGF, and FGF by interferon-gamma.
作者信息
Oleszak E
机构信息
Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
出版信息
Exp Cell Res. 1988 Dec;179(2):575-80. doi: 10.1016/0014-4827(88)90295-9.
Natural or recombinant human interferon-gamma abolishes the mitogenic activity of platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor on GM2767 or FS-4 human fibroblasts. Similarly murine interferon-gamma abolishes the mitogenic activity of these growth factors on BALB/C-3T3 fibroblasts. Inhibition of DNA synthesis by interferon-gamma was accomplished by blocking the transition of G0/G1 to S phase of the cell cycle. Addition of interferon-gamma 15 h after the addition of growth factors (when the cells had already entered the S phase) had no effect on DNA synthesis.
天然或重组人γ干扰素可消除血小板衍生生长因子、表皮生长因子和成纤维细胞生长因子对GM2767或FS - 4人成纤维细胞的促有丝分裂活性。同样，鼠γ干扰素可消除这些生长因子对BALB/C - 3T3成纤维细胞的促有丝分裂活性。γ干扰素对DNA合成的抑制作用是通过阻断细胞周期中G0/G1期向S期的转变来实现的。在添加生长因子15小时后（此时细胞已进入S期）添加γ干扰素对DNA合成没有影响。
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