Enriquez F J, Brooks B O, Cypess R H, David C S, Wassom D L
Department of Microbiology, Immunology and Parasitology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14850.
Exp Parasitol. 1988 Dec;67(2):221-6. doi: 10.1016/0014-4894(88)90069-0.
Strains of mice sharing common H-2 haplotypes but different genetic backgrounds, and H-2 congenic strains of mice differing only at H-2 genes were studied to assess the role of H-2 and non-H-2 genes in immunity to challenge infections with the nematode parasite Nematospiroides dubius. Strains of mice sharing the H-2k haplotype were uniformly more susceptible to challenge than strains expressing H-2q alleles, regardless of genetic background. However, in some cases strains of mice sharing the k or q haplotypes differed significantly in levels of resistance. Therefore, non-H-2 genes must influence the response observed. H-2 cogenic strains of mice differed markedly in their ability to resist challenge infections. Mice sharing the C57BL/10 background but expressing k alleles were very susceptible to challenge, while the H-2q, H-2f, and H-2s, haplotypes were associated with resistance. Studies of H-2 congenic recombinant strains of mice suggested that two H-2 genes influence the antiparasite response. One of these genes maps to the left of E alpha and the other to the D-end of the H-2 complex. It is concluded also that the unique configuration of H-2 genes in F1 hybrids contributes to increased resistance to challange.
研究了具有共同H-2单倍型但遗传背景不同的小鼠品系，以及仅在H-2基因上存在差异的H-2同源近交系小鼠，以评估H-2和非H-2基因在抵抗线虫寄生虫杜氏新线虫攻击感染的免疫中的作用。无论遗传背景如何，共享H-2k单倍型的小鼠品系比表达H-2q等位基因的品系对攻击普遍更敏感。然而，在某些情况下，共享k或q单倍型的小鼠品系在抗性水平上存在显著差异。因此，非H-2基因必定影响所观察到的反应。H-2同源近交系小鼠在抵抗攻击感染的能力上有显著差异。共享C57BL/10背景但表达k等位基因的小鼠对攻击非常敏感，而H-2q、H-2f和H-2s单倍型与抗性相关。对H-2同源重组系小鼠的研究表明，有两个H-2基因影响抗寄生虫反应。其中一个基因定位于Eα左侧，另一个定位于H-2复合体的D端。还得出结论，F1杂种中H-2基因的独特构型有助于增强对攻击的抗性。
