Bujo H, Nakai J, Kubo T, Fukuda K, Akiba I, Maeda A, Mishina M, Numa S
Department of Medical Chemistry, Kyoto University, Faculty of Medicine, Japan.
FEBS Lett. 1988 Nov 21;240(1-2):95-100. doi: 10.1016/0014-5793(88)80346-6.
Muscarinic acetylcholine receptor (mAChR) III expressed in Xenopus oocytes, like mAChR I, mediates activation of a Ca2+-dependent Cl- current, whereas mAChR IV, like mAChR II, principally induces activation of Na+ and K+ currents in a Ca2+-independent manner. mAChR III has a sensitivity to agonist of about one order of magnitude higher than that of mAChR I in mediating the Ca2+-dependent current response in Xenopus oocytes and in stimulating phosphoinositide hydrolysis in NG108-15 neuroblastoma-glioma hybrid cells. The agonist-binding affinity of mAChR III is also about one order of magnitude higher than that of mAChR I.
