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纯合子家族性高胆固醇血症伴左前降支冠状动脉狭窄，通过每周进行低密度脂蛋白单采术成功治疗16年，未行经皮冠状动脉介入治疗。

Homozygous familial hypercholesterolemia with stenosis of the left anterior descending coronary artery successfully treated with weekly low-density lipoprotein apheresis for 16 years without percutaneous coronary intervention.

作者信息

Yasu Takanori, Shimoyama Masahiro, Wada Hiroshi, Iwakura Tomohiro, Toyoda Shigeru, Kawabe Atsuhiko, Sugiyama Takushi

机构信息

Department of Cardiovascular Medicine and Nephrology Dokkyo Medical University Nikko Medical Center Nikko Japan.

Yuai Clinic Saitama Japan.

出版信息

Clin Case Rep. 2019 Jul 16;7(8):1608-1611. doi: 10.1002/ccr3.2299. eCollection 2019 Aug.

DOI:10.1002/ccr3.2299
PMID:31428402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6693054/
Abstract

We successfully treated a patient with homozygous familial hypercholesterolemia (HoFH) with stable coronary arterial disease using optimal medical therapy and low-density lipoprotein (LDL) apheresis for 16 years without percutaneous coronary intervention or bypass surgery. Intensive LDL lowering using apheresis and medication protected the patient from coronary atherosclerotic progression even in HoFH.

摘要

我们成功地为一名患有纯合子家族性高胆固醇血症（HoFH）且患有稳定冠状动脉疾病的患者进行了16年的最佳药物治疗和低密度脂蛋白（LDL）单采治疗，期间未进行经皮冠状动脉介入治疗或搭桥手术。即使在HoFH患者中，通过单采和药物强化降低LDL也能保护患者免受冠状动脉粥样硬化进展的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a13/6693054/ff005b8260ee/CCR3-7-1608-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a13/6693054/ff005b8260ee/CCR3-7-1608-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a13/6693054/ff005b8260ee/CCR3-7-1608-g001.jpg

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本文引用的文献

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