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通过使用疫苗持续抑制白细胞介素-18可改善三硝基苯磺酸诱导的小鼠结肠炎中的肠道炎症。

Sustained suppression of IL-18 by employing a vaccine ameliorates intestinal inflammation in TNBS-induced murine colitis.

作者信息

Guan Qingdong, Warrington Richard, Moreno Sem, Qing Gefei, Weiss Carolyn, Peng Zhikang

机构信息

Department of Immunology, University of Manitoba, Winnipeg R3E 3P4, Canada.

Department of Pediatrics & Child Health, University of Manitoba, Winnipeg, R3E 3P4, Canada.

出版信息

Future Sci OA. 2019 Jul 30;5(7):FSO405. doi: 10.2144/fsoa-2018-0125.

DOI:10.2144/fsoa-2018-0125
PMID:31428451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6695525/
Abstract

AIM

To develop IL-18 peptide-based virus-like particle vaccines that elicit autoantibodies against IL-18 and to evaluate the effects of the vaccines in murine colitis.

METHODS

Recombinant IL-18 vaccines were constructed, and the effects of the vaccines were evaluated in trinitrobenzene sulfonic acid-induced acute and chronic colitis in mice.

RESULTS

Two murine IL-18 peptide-based vaccines (A and D) were developed, which induced relative long-lasting specific antibodies against IL-18. Vaccine-immunized mouse antisera could partially block IL-18-induced IFN-γ production . Mice receiving vaccine D, not vaccine A, had a significant decrease in intestinal inflammation, collagen deposition and pro-inflammatory cytokine levels in colon tissue.

CONCLUSION

IL-18 vaccine may provide a potential therapeutic approach in the treatment of Crohn's disease.

摘要

目的

研发基于白细胞介素-18（IL-18）肽的病毒样颗粒疫苗，以诱导产生抗IL-18的自身抗体，并评估该疫苗对小鼠结肠炎的影响。

方法

构建重组IL-18疫苗，并在三硝基苯磺酸诱导的小鼠急性和慢性结肠炎中评估疫苗的效果。

结果

研发出两种基于小鼠IL-18肽的疫苗（A和D），它们能诱导产生相对持久的抗IL-18特异性抗体。疫苗免疫小鼠的抗血清可部分阻断IL-18诱导的γ干扰素产生。接受疫苗D而非疫苗A的小鼠，其结肠组织中的肠道炎症、胶原沉积和促炎细胞因子水平显著降低。

结论

IL-18疫苗可能为克罗恩病的治疗提供一种潜在的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/6695525/7ac403cccaeb/fsoa-05-405-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/6695525/d23e3d01f656/fsoa-05-405-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/6695525/7ac403cccaeb/fsoa-05-405-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/6695525/d23e3d01f656/fsoa-05-405-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/6695525/7ac403cccaeb/fsoa-05-405-g2.jpg

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